Welcome to the Biochemistry Quiz Questions Bank 🧬

Each question is a tiny scroll from Bodyland’s Biochemistry Hall.

Take your time — read, reflect, and choose wisely.

Click start when you’re ready to begin your journey!

📜 Welcome, Scrollkeeper.

You are about to enter the Biochemistry Chamber — where molecules whisper and pathways speak.

Stay focused. Each question is a living cell awaiting your understanding.

When ready, click “Begin Scroll Assessment” to unlock the first question.

May the Eternal Scientist — Jesus Christ, who designed every enzyme — grant you light and recall.

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Which type of cells in the body primarily contain GLUT-4 transporters? 💭 In the great city of Bodyland, glucose is like the main fuel that keeps every worker (cell) alive. But not every cell opens its gates the same way to let glucose in. Some gates respond to the gentle knock of insulin, while others open on their own. Which type of Bodyland cell primarily carries the insulin-responsive glucose gates known as GLUT-4 transporters? A. Adipocytes (Fat Cells) B. Erythrocytes (Red Blood Cells) C. Hepatocytes (Liver Cells) D. Osteocytes (Bone Cells) E. Pancreatic Cells (Beta Cells)

Deselect Answer

A. Adipocytes (Fat Cells)

B. Erythrocytes (Red Blood Cells)

C. Hepatocytes (Liver Cells)

D. Osteocytes (Bone Cells)

E. Pancreatic Cells (Beta Cells)

None

Which of the following cellular processes occurs without the breakdown (hydrolysis) of adenosine triphosphate (ATP) for energy? Let Demystify it In the bustling city of Bodyland, ATP coins are the currency that power almost every activity — from muscle work to molecular transport. Yet, some processes happen quietly without spending these precious energy coins. 🧩 Which process in Bodyland takes place without the use or hydrolysis of ATP?

Deselect Answer

Glycolysis

Myosin head contraction

Oxidative phosphorylation

Primary active transport of calcium ions

Primary active transport of sodium ions

None

Which of the following is a soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) protein that plays an important role in exocytosis?

Inside Bodyland’s nerve city, tiny messenger parcels wait at the edge of the cell, ready to deliver their chemical letters to the outside world. But the gate of the city doesn’t open by itself — it needs a specific molecular handshake between the vesicle and the cell membrane. This sacred handshake is performed by a group of proteins called SNAREs, which make sure every message is released at the right place and time.

Deselect Answer

Option A: Actin

Option B: Kinesin

Option C: Myosin

Option D: Synaptobrevin

Option E: Tubulin

None

Hint

What is the quaternary structure of a protein?

Think of a protein like a team made up of smaller players.

Each player (called a subunit) is already folded and ready to work — that’s its tertiary structure.

But when several of these subunits come together, link hands, and cooperate as one unit, they form the quaternary structure — the team!

These subunits are held together by gentle forces like hydrogen bonds, ionic bonds, and hydrophobic interactions, and sometimes by strong disulfide bridges that act like seatbelts keeping the team in shape.

💡 Example:

Haemoglobin → 4 subunits (2 alpha + 2 beta) working together to carry oxygen.

Antibody → 4 chains (2 heavy + 2 light) joined to defend Bodyland against invaders.

So, the quaternary structure simply means how many folded protein subunits come together and interact to do one job.

Deselect Answer

The arrangement of multiple protein subunits to form a functional complex

The arrangement of secondary structures in a protein

The covalent bonds that stabilise a protein's structure

The order of amino acids in a protein

The three-dimensional arrangement of a protein's domains

None

Hint

🧬 Bodyland Question: In the bustling Nucleus Palace of Bodyland, every messenger scroll (mRNA) must leave the royal DNA library and journey through the perilous Cytoplasmic Wilderness to reach the Ribosomal Factory. Before departure, each scroll receives a mysterious seal at its head — a small, shining mark known as the 5′ cap. 💭 In Bodyland terms: What is the true purpose of this royal 5′ cap placed upon every messenger scroll before it leaves the palace?

Deselect Answer

A. 🧠 Helps the messenger scroll fold into shape after reaching the Ribosomal Factory

B. 🛡️ Protects and stabilizes the royal scroll from being destroyed before it delivers its message

C. ⚙️ Assists the DNA scribes in copying the sacred text again

D. 🚪 Marks the starting point where ribosomes begin reading the scroll’s message aloud

E. ✨ Decorates the royal scroll to make it appear important without giving real protection

None

In the bloodstream highways of Bodyland, the liver sends out large lipid carriers called VLDLs — trucks loaded with triglyceride fuel for muscles and fat stores. As these VLDL trucks travel through capillaries, an enzyme stationed along the vessel walls begins removing their fat cargo, making them smaller and denser until they eventually become LDL particles that deliver cholesterol to body tissues. 👉 Which enzyme performs this fat-clearing role that transforms VLDL into LDL?

Deselect Answer

3-hydroxy-3-methylglutaryl co-enzyme A reductase

Lipoprotein lipase

Acetyl-co-enzyme A carboxylase

Cholesterol ester transfer protein

Fatty acid synthase

None

Proteins are composed of polypeptide chains that undergo stages of folding to form four different structure types. In which structure do multiple protein subunits come together to form a functional protein complex?

Deselect Answer

Option A: Primary structure

Option B: Secondary structure

Option C: Super-secondary structure

Option D: Tertiary structure

Option E: Quaternary structure

None

Hint

Deselect Answer

None

In the great archives of Bodyland’s genetic library, the DMD scroll, which encodes the muscle-strengthening protein known as dystrophin, suddenly ends mid-sentence — as if someone placed a red “STOP” mark before the story was complete. Which of the following best describes the result of this kind of genetic interruption?

Deselect Answer

A. A missing line in the genetic script caused by deletion of a few letters.

B. The opening switch of the gene fails to activate, silencing transcription.

C. Extra letters are inserted, shifting the entire genetic rhythm.

D. The ribosome stops reading too early, halting protein formation midway.

E. A single letter change replaces one amino acid with another, altering meaning but not ending the story.

None

10.

Which cell junction would be most useful in preventing movement of substances between cell membranes?

In Bodyland, each cell is like a little house with walls made of membranes. Between these houses run narrow alleys through which small mischievous molecules love to sneak. To stop these leaks, the city’s engineers build special junctions — structures that link cells together.

But not all junctions have the same job: some seal, some hold, some communicate, and some anchor.

Your task here is to identify which cell junction acts as the “watertight seal”, preventing substances from slipping between neighboring cell membranes.

Deselect Answer

Option A: Tight junctions

Option B: Desmosomes

Option C: Adherens junctions

Option D: Hemidesmosomes

Option E: Gap junctions

None

Hint

11.

Which of the following statements about the function of RNA polymerase is true?

Inside Bodyland’s grand library — the nucleus — the royal DNA scroll holds the secret codes of life.

The enzyme called RNA Polymerase acts as a faithful scribe, reading the DNA scroll to copy its words into RNA form.

But not every claim about this scribe’s job is true.

Choose which statement correctly describes how this enzyme works.

Deselect Answer

Option A: RNA polymerase requires a primer to initiate RNA synthesis.

Option B: RNA polymerase synthesises RNA in the 3' to 5' direction

Option C: polymerase is involved in both transcription and translation

Option D: RNA polymerase can proofread and correct errors during RNA synthesis

Option E: RNA polymerase binds to the promoter region of DNA to initiate transcription

None

Comment

Hint

12.

An enzyme’s active site is a complementary fit to the enzyme’s substrate. According to the induced fit model, what happens to the enzyme when the substrate binds?

This question helps you understand how enzymes and substrates interact during a reaction.

Enzymes are like specialized workers with uniquely shaped “hands” called active sites. The induced fit model explains that the enzyme’s shape isn’t completely rigid—it slightly adjusts when the substrate (the molecule it acts on) attaches.

Think of it like:

A glove that molds itself perfectly around your hand once you put it in.

Deselect Answer

Option A: The enzyme’s active site becomes less flexible

Option B: enzyme’s active site undergoes conformational changes to better fit the substrate

Option C: The enzyme catalyses the rate-limiting step

Option D: The enzyme denatures

Option E: The enzyme does not change

None

Hint

13.

In the grand kingdom of Bodyland, every protein is like a skilled worker carefully folded into the perfect shape to perform a specific duty — some carry messages, some build structures, others defend the realm. But sometimes, a few of these workers fold the wrong way — their shapes twist, collapse, or clump. Once this happens, chaos begins to spread through the city’s neural districts. 👉 So the question is: How do these misfolded protein workers cause devastating disorders like Alzheimer’s and Parkinson’s in Bodyland’s nervous capital?

Deselect Answer

These misfolded protein workers don’t just malfunction — they gather together like rebellious mobs, forming hard, insoluble fibril clumps that the brain’s cleanup crews can’t clear away. Over time, these stubborn clusters choke and damage nearby neurons, disturbing communication across Bodyland’s neural highways — the very chaos seen in diseases like Alzheimer’s and Parkinson’s.

These faulty proteins can tamper with Bodyland’s sacred instruction scrolls — the DNA code — causing tiny errors known as mutations. Once the genetic blueprint is altered, the cell begins producing even more misfolded or dysfunctional proteins, spreading confusion through the system and paving the way for disease.

They disrupt the normal genetic blueprint, causing subtle errors in DNA that lead to mutations — permanent changes in the code that can alter how proteins are built and how cells function.

They speed up the inner engines of brain neurons, raising their metabolic rate far beyond normal limits. At first, the neurons in Bodyland’s brain city seem hyperactive — burning energy rapidly — but soon this overdrive exhausts and damages them, leading to gradual cell burnout and neurodegeneration.

They trigger an excessive release of neurotransmitters — the brain’s chemical messengers — flooding Bodyland’s communication lines. This chemical overload disrupts balance between neurons, causing confusion, overstimulation, and eventually cell fatigue or damage as the brain’s circuits struggle to restore harmony.

When blood flow to the brain slows down, it’s like a power outage in Bodyland’s capital city. The brain’s neurons depend on a steady supply of oxygen and glucose, carried by the bloodstream, to keep their engines running. So when circulation decreases — whether from blocked arteries, low blood pressure, or damaged vessels — neurons begin to starve. Without enough oxygen (a condition called cerebral hypoxia) and glucose, they can’t produce ATP, their life energy coin. Soon, communication between neurons weakens, memory fades, and concentration slips. If the shortage continues, neurons begin to die, leading to cognitive decline or even stroke-like injury, which are major features in disorders such as vascular dementia. So.... Reduced blood flow = less oxygen and sugar → tired, starving neurons → brain slowdown and possible permanent damage.

None

14.

Which of the following statements best describes the mechanism by which vitamin D affects calcium homeostasis?

In the kingdom of Bodyland, the health of the bone towers and muscle fields depends on a quiet inspector who works whenever sunlight touches the land. This mysterious agent keeps Calcium, the great builder of Bodyland, moving to the right places — helping the bones stay strong and the nerves send signals.

But how does this inspector do it? Does he send messages to other workers? Does he open hidden gates? Or does he build the walls himself?

Think carefully about how this sunlight-born messenger keeps calcium levels balanced within Bodyland’s vast city.

Deselect Answer

Option A: Vitamin D directly stimulates the parathyroid gland to release parathyroid hormone

Option B: Vitamin D increases the absorption of calcium in the intestines and reabsorption in the kidneys

Option C: Vitamin D inhibits the absorption of calcium in the intestines and reabsorption in the kidneys

Option D: Vitamin D promotes the excretion of calcium in the urine

Option E: Vitamin D binds to calcium ions in the bloodstream, preventing their use in cellular processes

None

Hint

15.

In the royal laboratories of Bodyland, the mighty Haemoglobin Guild is known for its teamwork. Four skilled subunits — two Alpha knights and two Beta guardians — unite to carry the kingdom’s breath of life (oxygen) to every corner of the realm. But this unity is fragile and depends on invisible handshakes that keep the subunits holding together just right. Which of the following types of bonds mainly hold these subunits in harmony within haemoglobin’s quaternary structure?

Deselect Answer

A. Strong covalent chains that glue atoms tightly together.

B. Disulphide links formed by sulfur bridges between cysteine residues

C. Gentle hydrogen handshakes that stabilize the bond between subunits.

D. Glycosidic ties found mainly between sugar molecules.

E. Peptide links that stitch amino acids into a single chain.

None

16.

When ketone bodies are broken down during ketolysis to release acetyl-CoA, which major energy-producing cycle does this acetyl-CoA enter within the mitochondria?

Deselect Answer

Electron transport chain

Fatty acid beta-oxidation

Glycolysis

Krebs cycle

Link reaction

None

1 out of 16

✨ Scrollkeeper, Your Assessment is Complete ✨

The molecules have spoken. The scrolls of Biochemistry have unfolded before you,
and your answers have been weighed within the sacred chamber of understanding.

[if score_percentage greater_than="79"]

🌿 Magnificent! You have ascended through the pathways like an enzyme
perfectly fitted to its substrate. The Eternal Scientist smiles upon your diligence.

You have proven worthy of deeper scrolls — explore the next chambers soon.

[endif]

[if score_percentage greater_than="49" less_than="80"]

⚖️ Well done, Scrollkeeper. You walked the molecular maze with courage.
A few enzymes hesitated, but your curiosity kept the current of learning alive.

Return to the scrolls, refine your pathways, and illumination will multiply.

[endif]

[if score_percentage less_than="50"]

💡 Do not despair. Even the weakest reaction begins with activation energy.
You’ve stirred the molecules — now return to the scrolls, and soon, light will dawn.

Failure is never final in Bodyland; it’s simply a signal for deeper study.

[endif]

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